smooth muscle cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11831	LDN-27219		Others
	LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.		Others
T7133	Anagliptin	SK-0403	Proteasome , DPP-4
	Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.		Proteasome , DPP-4
T34280	Regrelor disodium	INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589	P2Y Receptor
	Regrelor disodium (INS 50589) is a p2y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, inhibits cell proliferation, and reduces inflammation.		P2Y Receptor
T1613	Hydralazine hydrochloride	Hydralazine HCl,Apresoline	MAO , HIF/HIF Prolyl-Hydroxylase
	Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...		MAO , HIF/HIF Prolyl-Hydroxylase
T3805	Prim-O-glucosylcimifugin	Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF , COX , JAK , NO Synthase
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.		TNF , COX , JAK , NO Synthase
T2441	TAS-301	TAS 301	PKC
	TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.		PKC
T68002L	(R)-Naroparcil	4-[4-[(5-Thio-α-D-xylopyranosyl)thio]benzoyl]benzonitrile(Isomer-120819-70-7)	Others
	(R)-Naroparcil is an isomer of Naroparcil. Naroparcil, a 4-methylumbelliferyl beta-D-xyloside analog, is associated with vascular smooth muscle cell proliferation and inhibits thrombus formation in the Wessler slough mod...		Others
T60388	MIF098		Others
	MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be ...		Others
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T1139	Salbutamol	Albuterol,AH-3365	Adrenergic Receptor
	Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ...		Adrenergic Receptor
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
T26830	BK 129	BK-129,BK129
	BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.
T15105	Dexloxiglumide		Others
	Dexloxiglumide, an active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). It is a selective antagonist of cholecystokinin type A (CCKA) receptors.		Others
T27325	FK-739 free acid	FK-739,FK 739,FK739
	FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125...
TN2075	Pimaric acid		MMP , p38 MAPK , NF-κB
	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.		MMP , p38 MAPK , NF-κB
T27189	DL-threo dihydrosphingosine	DL-Safingol,DTD,DL threo dihydrosphingosine
	DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- an...
T36214	16,16-dimethyl Prostaglandin E1	16,16-dimethyl Prostaglandin E1
	16,16-dimethyl Prostaglandin E1 is a PGE1 (T1626) analog that induces bronchoconstriction and vascular smooth muscle contraction and inhibits indomethacin-induced cell elongation.
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ...
T35585	I-BOP
	I-BOP is an agonist (KD=0.61 nM) at the thromboxane A2 receptor (TP). I-BOP promotes cell proliferation by activating the PI3K pathway in vascular smooth muscle.